Download and read online Dance to the Tune of Life in PDF and EPUB
Download and read online Dance to the Tune of Life in PDF and EPUB In this thought-provoking book, Denis Noble formulates the theory of biological relativity, emphasising that living organisms operate at multiple levels of complexity and must therefore be analysed from a multi-scale, relativistic perspective. Noble explains that all biological processes operate by means of molecular, cellular and organismal networks. The interactive nature of these fundamental processes is at the core of biological relativity and, as such, challenges simplified molecular reductionism. Noble shows that such an integrative view emerges as the necessary consequence of the rigorous application of mathematics to biology. Drawing on his pioneering work in the mathematical physics of biology, he shows that what emerges is a deeply humane picture of the role of the organism in constraining its chemistry, including its genes, to serve the organism as a whole, especially in the interaction with its social environment. This humanistic, holistic approach challenges the common gene-centred view held by many in modern biology and culture.
Download and read online Dance to the Tune of Life in PDF and EPUB
Download and read online Dance to the Tune of Life in PDF and EPUB
Download and read online The Music of Life in PDF and EPUB What is Life? Decades of research have resulted in the full mapping of the human genome - three billion pairs of code whose functions are only now being understood. The gene's eye view of life, advocated by evolutionary biology, sees living bodies as mere vehicles for the replication of the genetic codes. But for a physiologist, working with the living organism, the view is a very different one. Denis Noble is a world renowned physiologist, and sets out an alternative view to the question - one that becomes deeply significant in terms of the living, breathing organism. The genome is not life itself. Noble argues that far from genes building organisms, they should be seen as prisoners of the organism. The view of life presented in this little, modern, post-genome project reflection on the nature of life, is that of the systems biologist: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, that is life. It is a kind of music. Including stories from Noble's own research experience, his work on the heartbeat, musical metaphors, and elements of linguistics and Chinese culture, this very personal and at times deeply lyrical book sets out the systems biology view of life.
Download and read online Evolution in PDF and EPUB James A. Shapiro proposes an important new paradigm for understanding biological evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular evidence that tests the conventional scientific view of evolution based on the neo-Darwinian synthesis, shows why this view is inadequate to today's evidence, and presents a compelling alternative view of the evolutionary process that reflects the shift in life sciences towards a more information- and systems-based approach in Evolution: A View from the 21st Century. Shapiro integrates advances in symbiogenesis, epigenetics, and saltationism into a unified approach that views evolutionary change as an active cell process, regulated epigenetically and capable of making rapid large changes by horizontal DNA transfer, inter-specific hybridization, whole genome doubling, symbiogenesis, or massive genome restructuring. Evolution marshals extensive evidence in support of a fundamental reinterpretation of evolutionary processes, including more than 1,100 references to the scientific literature. Shapiro's work will generate extensive discussion throughout the biological community, and may significantly change your own thinking about how life has evolved. It also has major implications for evolutionary computation, information science, and the growing synthesis of the physical and biological sciences.
Download and read online From Matter to Life in PDF and EPUB Recent advances suggest that the concept of information might hold the key to unravelling the mystery of life's nature and origin. Fresh insights from a broad and authoritative range of articulate and respected experts focus on the transition from matter to life, and hence reconcile the deep conceptual schism between the way we describe physical and biological systems. A unique cross-disciplinary perspective, drawing on expertise from philosophy, biology, chemistry, physics, and cognitive and social sciences, provides a new way to look at the deepest questions of our existence. This book addresses the role of information in life, and how it can make a difference to what we know about the world. Students, researchers, and all those interested in what life is and how it began will gain insights into the nature of life and its origins that touch on nearly every domain of science.
Download and read online Molecular Biology of Assemblies and Machines in PDF and EPUB Molecular Biology of Assemblies and Machines presents a comprehensive narrative describing the structures of macromolecular complexes and how they assemble and interact. Richly illustrated, it is written for advanced undergraduates, graduate students, and researchers in biochemistry, structural biology, molecular biology, biophysics, cell biology, and microbiology, and will also appeal to those in chemistry, immunology, and medicine. Essentially all major biological activities are performed by assemblies of macromolecules (proteins, RNA, and DNA) acting in concert. These assemblies are dynamic and many are endowed with machine-like properties. This unique book explores the molecular mechanisms employed at the critical level between individual macromolecules and cells and organelles.
Download and read online Evolution 2 0 in PDF and EPUB In the ongoing debate about evolution, science and faith face off. But the truth is both sides are right and wrong. In one corner: Atheists like Richard Dawkins, Daniel Dennett, and Jerry Coyne. They insist evolution happens by blind random accident. Their devout adherence to Neo-Darwinism omits the latest science, glossing over crucial questions and fascinating details. In the other corner: Intelligent Design advocates like William Dembski, Stephen Meyer, and Michael Behe. Many defy scientific consensus, maintaining that evolution is a fraud and rejecting common ancestry outright. There is a third way. Evolution 2.0 proves that, while evolution is not a hoax, neither is it random nor accidental. Changes are targeted, adaptive, and aware. You’ll discover: How organisms re-engineer their genetic destiny in real time Amazing systems living things use to re-design themselves Every cell is armed with machinery for editing its own DNA The five amazing tools organisms use to alter their genetics 70 years of scientific discoveries—of which the public has heard virtually nothing! Perry Marshall approached evolution with skepticism for religious reasons. As an engineer, he rejected the concept of organisms randomly evolving. But an epiphany—that DNA is code, much like data in our digital age—sparked a 10-year journey of in-depth research into more than 70 years of under-reported evolutionary science. This led to a new understanding of evolution—an evolution 2.0 that not only furthers technology and medicine, but fuels our sense of wonder at life itself. This book will open your eyes and transform your thinking about evolution and God. You’ll gain a deeper appreciation for our place in the universe. You’ll see the world around you as you’ve never seen it before. Evolution 2.0 pinpoints the central mystery of biology, offering a multimillion dollar technology prize at naturalcode.org to the first person who can solve it.
Download and read online Life on the Edge in PDF and EPUB New York Times Bestseller and an Amazon Best Science Book of 2015 Life is the most extraordinary phenomenon in the known universe; but how did it come to be? Even in an age of cloning and artificial biology, the remarkable truth remains: nobody has ever made anything living entirely out of dead material. Life remains the only way to make life. Are we still missing a vital ingredient in its creation? Like Richard Dawkins' The Selfish Gene, which provided a new perspective on how evolution works, Life on the Edge alters our understanding of our world's fundamental dynamics. Bringing together first-hand experience at the cutting edge of science with unparalleled gifts of explanation, Jim Al-Khalili and Johnjoe Macfadden reveal that missing ingredient to be quantum mechanics; the phenomena that lie at the heart of this most mysterious of sciences. Drawing on recent ground-breaking experiments around the world, each chapter in Life on the Edge engages by illustrating one of life's puzzles: How do migrating birds know where to go? How do we really smell the scent of a rose? How do our genes copy themselves with such precision? Life on the Edge accessibly reveals how quantum mechanics can answer these probing questions of the universe. Guiding the reader through the rapidly unfolding discoveries of the last few years, Al-Khalili and McFadden communicate the excitement of the explosive new field of quantum biology and its potentially revolutionary applications, while offering insights into the biggest puzzle of all: what is life? As they brilliantly demonstrate in these groundbreaking pages, life exists on the quantum edge. – Winner, Stephen Hawking Medal for Science Communication
Download and read online The Systems View of Life in PDF and EPUB The first volume to integrate life's biological, cognitive, social, and ecological dimensions into a single, coherent framework.
Download and read online The Paradox of Evolution in PDF and EPUB This book examines a little-noted contradiction inherent in the two essential elements of Darwin's theory of biological evolution--natural selection and reproduction. Physiologist Stephen Rothman makes the revolutionary claim that the evolution of life's complex and diverse reproductive mechanisms is not the consequence of natural selection. In so doing, he exposes the deepest question possible about life's nature--its reason for being. In meticulously detailed but accessible terms he lays out the crux of the paradox and offers an intriguing solution within a naturalistic framework. In an ostensibly purposeless universe, somehow purposeful life has evolved. For all living things there are two overarching purposes: survival and the creation of new life. Natural selection is about the survival of existing life, but has no interest in life's future, about whether it persists or perishes. By contrast, reproduction is only about the future of life, and has no interest in existing life except as a means to that end. Where do these purposes come from? As Rothman demonstrates, at every level life is wired to react to danger. Counterintuitively, without the danger to its existence, life would not have come into being. As for reproduction, nature's destructive forces drive the creation of new life. Written with great clarity and informed by deep learning, this elegant, thoughtful work tackles some of the most challenging questions raised by the theory of evolution, while calling to mind Darwin's famous words from the conclusion of On the Origin of Species: "There is a grandeur in this view of life."
Download and read online Void in PDF and EPUB The rising star author of The Physics of Wall Street explores why “nothing” may hold the key to the next era of theoretical physics James Owen Weatherall’s previous book, The Physics of Wall Street, was a New York Times best-seller and named one of Physics Today’s five most intriguing books of 2013. In his newest volume, he takes on a fundamental concept of modern physics: nothing. The physics of stuff—protons, neutrons, electrons, and even quarks and gluons—is at least somewhat familiar to most of us. But what about the physics of nothing? Isaac Newton thought of empty space as nothingness extended in all directions, a kind of theater in which physics could unfold. But both quantum theory and relativity tell us that Newton’s picture can’t be right. Nothing, it turns out, is an awful lot like something, with a structure and properties every bit as complex and mysterious as matter. In his signature lively prose, Weatherall explores the very nature of empty space—and solidifies his reputation as a science writer to watch.
Download and read online Phylogenetic Networks in PDF and EPUB The evolutionary history of species is traditionally represented using a rooted phylogenetic tree. However, when reticulate events such as hybridization, horizontal gene transfer or recombination are believed to be involved, phylogenetic networks that can accommodate non-treelike evolution have an important role to play. This book provides the first interdisciplinary overview of phylogenetic networks. Beginning with a concise introduction to both phylogenetic trees and phylogenetic networks, the fundamental concepts and results are then presented for both rooted and unrooted phylogenetic networks. Current approaches and algorithms available for computing phylogenetic networks from different types of datasets are then discussed, accompanied by examples of their application to real biological datasets. The book also summarises the algorithms used for drawing phylogenetic networks, along with the existing software for their computation and evaluation. All datasets, examples and other additional information and links are available from the book's companion website at www.phylogenetic-networks.org.
Download and read online The One Straw Revolution in PDF and EPUB Call it “Zen and the Art of Farming” or a “Little Green Book,” Masanobu Fukuoka’s manifesto about farming, eating, and the limits of human knowledge presents a radical challenge to the global systems we rely on for our food. At the same time, it is a spiritual memoir of a man whose innovative system of cultivating the earth reflects a deep faith in the wholeness and balance of the natural world. As Wendell Berry writes in his preface, the book “is valuable to us because it is at once practical and philosophical. It is an inspiring, necessary book about agriculture because it is not just about agriculture.” Trained as a scientist, Fukuoka rejected both modern agribusiness and centuries of agricultural practice, deciding instead that the best forms of cultivation mirror nature’s own laws. Over the next three decades he perfected his so-called “do-nothing” technique: commonsense, sustainable practices that all but eliminate the use of pesticides, fertilizer, tillage, and perhaps most significantly, wasteful effort. Whether you’re a guerrilla gardener or a kitchen gardener, dedicated to slow food or simply looking to live a healthier life, you will find something here—you may even be moved to start a revolution of your own.